Hyperpolarized 129Xe Time-of-Flight MR Imaging of Perfusion and Brain Function.

ABSTRACT: Perfusion measurements can provide vital information about the homeostasis of an organ and can therefore be used as biomarkers to diagnose a variety of cardiovascular, renal, and neurological diseases. Currently, the most common techniques to measure perfusion are 15O positron emission tomography (PET), xenon-enhanced computed tomography (CT), single photon emission computed tomography (SPECT), dynamic contrast enhanced (DCE) MRI, and arterial spin labeling (ASL) MRI. Here, we show how regional perfusion can be quantitively measured with magnetic resonance imaging (MRI) using time-resolved depolarization of hyperpolarized (HP) xenon-129 (129Xe), and the application of this approach to detect changes in cerebral blood flow (CBF) due to a hemodynamic response in response to brain stimuli. Th

SUBMITTER: Shepelytskyi Y 

PROVIDER: S-EPMC7554935 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature