Antimicrobial Activities of Different Fractions from Mucus of the Garden Snail <i>Cornu aspersum</i>.

ABSTRACT: Natural products have long played a major role in medicine and science. The garden snail Cornu aspersum is a rich source of biologically active natural substances that might be an important source for new drugs to treat human disease. Based on our previous studies, nine fractions containing compounds with Mw <3 kDa; <10 kDa; <20 kDa; >20 kDa; >30 kDa>50 kDa and between 3 and 5 kDa; 5 and 10 kDa; and 10 and 30 kDa were purified from the mucus of C. aspersum and analyzed by tandem mass spectrometry (MALDI-TOF/TOF). Seventeen novel peptides with potential antibacterial activity were identified by de novo MS/MS sequencing using tandem mass spectrometry. The different fractions were tested for antibacterial activity against Gram^─ (Pseudomonas aureofaciens and

SUBMITTER: Dolashki A 

PROVIDER: S-EPMC7554965 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature