Ontology highlight
ABSTRACT:
SUBMITTER: Michelini S
PROVIDER: S-EPMC7555018 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200916 18
TIE1 is a cell surface protein expressed in endothelial cells. Involved in angiogenesis and lymphangiogenesis, including morphogenesis of lymphatic valves, TIE1 is important for lymphatic system functional integrity. The main purpose of this study was to identify different variants in the <i>TIE1</i> gene that could be associated with lymphatic malformations or dysfunction and predisposition for lymphedema. In a cohort of 235 Italian lymphedema patients, who tested negative for variants in known ...[more]