Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.

ABSTRACT: The serotonin 2A receptor (5-HT2AR) is implicated in the pathophysiology and treatment of various psychiatric disorders. [¹⁸ F]altanserin and [¹¹ C]Cimbi-36 positron emission tomography (PET) allow for high-resolution imaging of 5-HT2AR in the living human brain. Cerebral 5-HT2AR binding is strongly genetically determined, though the impact of specific variants is poorly understood. Candidate gene studies suggest that HTR2A single nucleotide polymorphisms including rs6311/rs6313, rs6314, and rs7997012 may influence risk for psychiatric disorders and mediate treatment response. Although known to impact in vitro expression of 5-HT2AR or other serotonin (5-HT) proteins, their effect on human in vivo brain 5-HT2AR binding has as of yet been insufficiently studied. We thus

SUBMITTER: Spies M 

PROVIDER: S-EPMC7555071 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature