Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells.

ABSTRACT: The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD). The AMD pathogenesis includes both increased oxidative stress and complement dysregulation. Physiological sources of oxidative stress in the retina are well known, while complement sources and regulation are still under debate. Using human primary RPE (hpRPE) cells, we have established a model to investigate complement component expression on transcript and protein level in AMD-risk and non-risk hpRPE cells. We evaluated the effect of properdin, a complement stabilizer, on the hpRPE cell-dependent complement profile exposed to oxidative stress. hpRPE cells ex

SUBMITTER: Schafer N 

PROVIDER: S-EPMC7555107 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature