Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing.

ABSTRACT: Sepsis represents a serious medical problem accounting for numerous deaths of critically ill patients in intensive care units (ICUs). An early, sensitive, and specific diagnosis is considered a key element for improving the outcome of sepsis patients. In addition to classical laboratory markers, ICU scoring systems and serum miRNAs are discussed as potential sepsis biomarkers. In the present prospective observational study, the suitability of miRNAs in sepsis diagnosis was tested based on proper validated and normalized data (i.e., absolute quantification by means of Droplet Digital PCR (ddPCR)) in direct comparison to classical sepsis markers and ICU scores within the same patient cohort. Therefore, blood samples of septic intensive care patients (n = 12) taken at day of admission

SUBMITTER: Link F 

PROVIDER: S-EPMC7555112 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature