Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a complex and heterogeneous disorder involving multiple genetic and environmental influences. Although a wide range of PD risk factors and clinical markers for the symptomatic motor stage of the disease have been identified, there are still no reliable biomarkers available for the early pre-motor phase of PD and for predicting disease progression. High-throughput RNA-based biomarker profiling and modeling may provide a means to exploit the joint information content from a multitude of markers to derive diagnostic and prognostic signatures. In the field of PD biomarker research, currently, no clinically validated RNA-based biomarker models are available, but previous studies reported several significantly disease-associated changes in RNA abundances and activitie

SUBMITTER: Acharya S 

PROVIDER: S-EPMC7555192 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature