Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces.

ABSTRACT: The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles appears to be promising, since magnetic fields can act at a distance without interactions with the surrounding biological system. To control biological processes at a subcellular spatial resolution, magnetic nanoparticles can be used either to induce biochemical reactions locally or to apply forces on different elements of the cell. Here, we show that cell migration and neurite outgrowth can be directed by the forces produced by a switchable parallelized array of micro-magnetic pillars, following the passive uptake of nanoparticles. Using live cel

SUBMITTER: Bongaerts M 

PROVIDER: S-EPMC7555211 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature