Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review.

ABSTRACT: Knee osteoarthritis (OA) is a condition mainly characterized by cartilage degradation. Currently, no effective treatment exists to slow down the progression of OA-related cartilage damage. Selective COX-2 inhibitors may, next to their pain killing properties, act chondroprotective in vivo. To determine whether the route of administration is important for the efficacy of the chondroprotective properties of selective COX-2 inhibitors, a systematic review was performed according to the PRISMA guidelines. Studies investigating OA-related cartilage damage of selective COX-2 inhibitors in vivo were included. Nine of the fourteen preclinical studies demonstrated chondroprotective effects of selective COX-2 inhibitors using systemic administration. Five clinical studies were included and, although

SUBMITTER: Timur UT 

PROVIDER: S-EPMC7555215 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature