Microgravity Modulates Effects of Chemotherapeutic Drugs on Cancer Cell Migration.

ABSTRACT: Microgravity or the condition of apparent weightlessness causes bone, muscular and immune system dysfunctions in astronauts following spaceflights. These organ and system-level dysfunctions correlate with changes induced at the single cell level both by simulated microgravity on earth as well as microgravity conditions in outer space (as in the international space station). Reported changes in single bone cells, muscle cells and white blood cells include structural/morphological abnormalities, changes in gene expression, protein expression, metabolic pathways and signaling pathways, suggesting that cells mount some response or adjustment to microgravity. However, the implications of such adjustments on many cellular functions and responses are not clear largely because the primary mechanis

SUBMITTER: Prasanth D 

PROVIDER: S-EPMC7555236 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature