Electrical Neurostimulation Promotes Brown Adipose Tissue Thermogenesis.

ABSTRACT:

Background

Brown adipose tissue (BAT) is present in humans and rodents, and contributes to energy expenditure by converting energy stored in lipids and glucose into heat. Beta adrenergic receptor (β-AR) agonists have been proposed as pharmacological tools to activate BAT, but they lack selectivity for this tissue. This study aimed to investigate the possibility to apply electrical neurostimulation as a novel approach to activate BAT by promoting the sympathetic outflow towards BAT.

Methods

Male C57BL/6J mice were treated with either unilateral electrical neurostimulation of interscapular BAT or with the β3-AR agonist CL316,243. Thermogenesis, nutrient uptake by BAT and downstream signaling of adrenergic receptors in BAT were examined.

Results

Electrical neurostimulati

SUBMITTER: Li Z 

PROVIDER: S-EPMC7555256 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature