The Hidden Fragility in the Heart of the Athletes: A Review of Genetic Biomarkers.

ABSTRACT: Sudden cardiac death (SCD) is a devastating event which can also affect people in apparent good health, such as young athletes. It is known that intense and continuous exercise along with a genetic background that predisposes a person to the risk of fatal arrhythmias is a trigger for SCD. Therefore, knowledge of the athlete's genetic conditions underlying the onset of SCD must be extended, in order to develop new effective prevention and/or therapeutic strategies. Arrhythmic features occur across a broad spectrum of cardiac diseases, sometimes presenting with overlapping phenotypes. The genetic basis of arrhythmogenic disorders has been greatly highlighted in the last 30 years, and has shown marked heterogeneity. The advent of next-generation sequencing has constantly updated our understan

SUBMITTER: Barretta F 

PROVIDER: S-EPMC7555257 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature