Immunoglobulins or Antibodies: IMGT^® Bridging Genes, Structures and Functions.

ABSTRACT: IMGT^®, the international ImMunoGeneTics^® information system founded in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), marked the advent of immunoinformatics, a new science at the interface between immunogenetics and bioinformatics. For the first time, the immunoglobulin (IG) or antibody and T cell receptor (TR) genes were officially recognized as 'genes' as well as were conventional genes. This major breakthrough has allowed the entry, in genomic databases, of the IG and TR variable (V), diversity (D) and joining (J) genes and alleles of Homo sapiens and of other jawed vertebrate species, based on the CLASSIFICATION axiom. The second major breakthrough has been the IMGT unique numbering and the IMGT Collier de Perles for the V and constant (C

SUBMITTER: Lefranc MP 

PROVIDER: S-EPMC7555362 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature