Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer.

ABSTRACT: Androgen receptor (AR)-mediated signaling is essential for the growth and differentiation of the normal prostate and is the primary target for androgen deprivation therapy in prostate cancer. Tat interactive protein 60 kDa (Tip60) is a histone acetyltransferase that is critical for AR activation. It is well known that cancer cells rewire their metabolic pathways in order to sustain aberrant proliferation. Growing evidence demonstrates that the AR and Tip60 modulate key metabolic processes to promote the survival of prostate cancer cells, in addition to their classical roles. AR activation enhances glucose metabolism, including glycolysis, tricarboxylic acid cycle and oxidative phosphorylation, as well as lipid metabolism in prostate cancer. The AR also interacts with other metabolic regula

SUBMITTER: Tan KN 

PROVIDER: S-EPMC7555377 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature