Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia.

ABSTRACT:

Background

Immunohistochemical quantification of the immune response is prognostic for colorectal cancer (CRC). Here, we evaluate the suitability of alternative immune classifiers on prognosis and assess whether they relate to biological features amenable to targeted therapy.

Methods

Overall survival by immune (CD3, CD4, CD8, CD20 and FOXP3) and immune-checkpoint (ICOS, IDO-1 and PD-L1) biomarkers in independent CRC cohorts was evaluated. Matched mutational and transcriptomic data were interrogated to identify associated biology.

Results

Determination of immune-cold tumours by combined low-density cell counts of CD3, CD4 and CD8 immunohistochemistry constituted the best prognosticator across stage II-IV CRC, particularly in patients with stage IV disease (HR 1.98 [95%

SUBMITTER: Craig SG 

PROVIDER: S-EPMC7555485 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature