Propranolol-induced inhibition of unconditioned stimulus-reactivated fear memory prevents the return of fear in humans.

ABSTRACT: Fear memories can be reactivated by a fear-associated conditioned stimulus (CS) or unconditioned stimulus (US) and then undergo reconsolidation. Propranolol administration during CS retrieval-induced reconsolidation can impair fear memory that is specific to the reactivated CS. However, from a practical perspective, the US is often associated with multiple CSs, and each CS can induce a fear response. The present study sought to develop and test a US-based memory retrieval interference procedure with propranolol to disrupt the original fear memory and eliminate all CS-associated fear responses in humans. We recruited 127 young healthy volunteers and conducted three experiments. All of the subjects acquired fear conditioning, after which they received the β-adrenergic receptor antagonist pro

SUBMITTER: Deng J 

PROVIDER: S-EPMC7555531 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature