The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum.

ABSTRACT: Dissemination and survival of ascomycetes is through asexual spores. The brlA gene encodes a C₂H₂-type zinc-finger transcription factor, which is essential for asexual development. Penicillium expansum causes blue mold disease and is the main source of patulin, a mycotoxin that contaminates apple-based food. A P. expansum PeΔbrlA deficient strain was generated by homologous recombination. In vivo, suppression of brlA completely blocked the development of conidiophores that takes place after the formation of coremia/synnemata, a required step for the perforation of the apple epicarp. Metabolome analysis displayed that patulin production was enhanced by brlA suppression, explaining a higher in vivo aggressiveness compared to the

SUBMITTER: Zetina-Serrano C 

PROVIDER: S-EPMC7555563 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature