Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis.

ABSTRACT:

Background

A meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer.

Methods

We systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence interval (CI).

Results

Seven articles involving 3836 healthy controls and 3637 patients were included in this meta-analysis. TERT rs2736098 polymorphism was significantly related to lung cancer incidence (AA vs. GG: OR=1.83, 95% CI=1.58-2.12; AG vs. GG: OR=1.21, 95% CI=1.10-1.34; Dominant model: OR=1.33, 95% CI=1.22-1.46; Recessive m

SUBMITTER: Wang M 

PROVIDER: S-EPMC7555572 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature