Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma.

ABSTRACT: Melanoma is the least common form of skin cancer and is associated with the highest mortality. Where melanoma is mostly unresponsive to conventional therapies (e.g., chemotherapy), BRAF inhibitor treatment has shown improved therapeutic outcomes. Photodynamic therapy (PDT) relies on a light-activated compound to produce death-inducing amounts of reactive oxygen species (ROS). Their capacity to selectively accumulate in tumor cells has been confirmed in melanoma treatment with some encouraging results. However, this treatment approach has not reached clinical fruition for melanoma due to major limitations associated with the development of resistance and subsequent side effects. These adverse effects might be bypassed by immunotherapy in the form of antibody-drug conjugates (ADCs) relying o

SUBMITTER: Biteghe FAN 

PROVIDER: S-EPMC7555584 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature