Ontology highlight
ABSTRACT:
SUBMITTER: Lien LM
PROVIDER: S-EPMC7555624 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200922 18
Previously, we reported that phospholipase D1 (PLD1) and PLD2 inhibition by selective PLD1 and PLD2 inhibitors could prevent platelet aggregation in humans, but not in mice. Moreover, only the PLD1 inhibitor, but not PLD2 inhibitor, could effectively prevent thrombus formation in mice, indicating that PLD might play different roles in platelet function in humans and mice. Although PLD1 and PLD2 were reported to be implicated in thrombotic events, the role of PLD in mice remains not completely cl ...[more]