Catalase T-Deficient Fission Yeast Meiocytes Show Resistance to Ionizing Radiation.

ABSTRACT: Environmental stress, reactive oxygen species (ROS), or ionizing radiation (IR) can induce adverse effects in organisms and their cells, including mutations and premature aging. DNA damage and its faulty repair can lead to cell death or promote cancer through the accumulation of mutations. Misrepair in germ cells is particularly dangerous as it may lead to alterations in developmental programs and genetic disease in the offspring. DNA damage pathways and radical defense mechanisms mediate resistance to genotoxic stresses. Here, we investigated, in the fission yeast Schizosaccharomyces pombe, the role of the H₂O₂-detoxifying enzyme cytosolic catalase T (Ctt1) and the Fe²⁺/Mn²⁺ symporter Pcl1 in protecting meiotic chromosome dynamics and gam

SUBMITTER: Muhtadi R 

PROVIDER: S-EPMC7555645 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature