Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions.

ABSTRACT: When in a particular scientific field, major progress is rapidly reached after a long period of relative stand-still, this is often achieved by the development or exploitation of new techniques and methods. A striking example is the new insights brought into the understanding of the gating mechanism of the transient receptor potential melastatin type 2 cation channel (TRPM2) by cryogenic electron microscopy structure analysis. When conventional methods are complemented by new ones, it is quite natural that established researchers are not fully familiar with the possibilities and limitations of the new method. On the other hand, newcomers may need some assistance in perceiving the previous knowledge in detail; they may not realize that some of their interpretations are at odds with previous

SUBMITTER: Kuhn FJP 

PROVIDER: S-EPMC7555694 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature