A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children.

ABSTRACT: Background: Asthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota signatures that characterize the clinical allergic asthma phenotype in obese children. Methods: We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers, metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover, allergic child

SUBMITTER: Gomez-Llorente MA 

PROVIDER: S-EPMC7555790 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature