Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study.

ABSTRACT: DNA mismatch repair (MMR) is a system for repairing errors in DNA replication. Cancer cells with MMR deficiency can have immunohistochemical loss of MMR protein expression leading to a hypermutable phenotype that may correlate with anti-PD1 efficacy. Scant data exist about immunohistochemical loss of MMR protein expression in high-grade gliomas (HGG). We performed a large multicenter retrospective study to investigate the frequency and the prognostic role of immunohistochemical loss of MMR protein expression in HGG patients; we nevertheless evaluated the association between this status and clinical or molecular characteristics. Immunohistochemical loss of MMR protein expression was recorded as partial or complete loss of at least 1 MMR protein. We analyzed the expression of MMR proteins in

SUBMITTER: Caccese M 

PROVIDER: S-EPMC7555820 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature