Association of obesity status and metabolic syndrome with site-specific cancers: a population-based cohort study.

ABSTRACT:

Background

Obesity and metabolic syndrome (MetS) appear in clusters and are both associated with an increased risk of cancer. However, it remains unknown whether obesity status with or without MetS increases the risk of site-specific cancers.

Methods

We used data derived from 390,575 individuals (37-73 years old) from the UK Biobank who were enrolled from 2006-2016 with a median of 7.8 years of follow-up. Obesity was defined by BMI ≥ 30 kg/m² and MetS was defined by the criteria of the Adult Treatment Panel-III (ATP-III). Cox proportional hazards models were used to investigate the associations of BMI and MetS with 22 cancers.

Results

Metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) phenotypes represented 6.7% and 17.9% of the t

SUBMITTER: Cao Z 

PROVIDER: S-EPMC7555864 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature