Engineering Photosensory Modules of Non-Opsin-Based Optogenetic Actuators.

ABSTRACT: Optogenetic (photo-responsive) actuators engineered from photoreceptors are widely used in various applications to study cell biology and tissue physiology. In the toolkit of optogenetic actuators, the key building blocks are genetically encodable light-sensitive proteins. Currently, most optogenetic photosensory modules are engineered from naturally-occurring photoreceptor proteins from bacteria, fungi, and plants. There is a growing demand for novel photosensory domains with improved optical properties and light-induced responses to satisfy the needs of a wider variety of studies in biological sciences. In this review, we focus on progress towards engineering of non-opsin-based photosensory domains, and their representative applications in cell biology and physiology. We summarize curren

SUBMITTER: Lu X 

PROVIDER: S-EPMC7555876 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature