Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells.

ABSTRACT: Human colon cancer is the third leading cause of mortality in the United States and worldwide. Chemoprevention using diet is widely accepted as a promising approach for cancer management. Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds. In the current study, we evaluated the anticancer properties of a high phenolic sorghum bran extract prepared using 70% ethanol with 5% citric acid solvent at room temperature. A significant dose-dependent suppression of cell proliferation was observed in human colon cancer cells treated with the high phenolic sorghum bran extract. Apoptosis and S phase growth arrest were induced, while cell migration and invasion were inhibi

SUBMITTER: Lee SH 

PROVIDER: S-EPMC7556115 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature