Hematopoietic Gene Expression Regulation Through m⁶A Methylation Predicts Prognosis in Stage III Colorectal Cancer.

ABSTRACT:

Background

Methylation of N6 adenosine (m⁶A) plays important regulatory roles in diverse biological processes. The purpose of this research was to explore the potential mechanism of m⁶A modification level on the clinical outcome of stage III colorectal cancer (CRC).

Methods

Gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) were adopted to reveal the signal pathway which was most likely affected by m⁶A methylation. The linear models for microarray data (LIMMA) method and the least absolute shrink-age and selection operator (LASSO) Cox regression model were used to identify the signature. The signature can sensitively separate the patients into high and low risk indicating the relapse-free survival (RFS) time based on t

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC7556240 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature