Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model.

ABSTRACT: Organophosphorus (OP) insecticide self-poisoning causes over 100,000 global deaths annually. Around a third of patients are intubated and up to half of these can die. Post-mortem analysis of OP poisoned patients' lungs reveals consolidation, edema and hemorrhage, suggesting that direct or indirect lung damage may contribute to mortality. The lung injury caused by these formulated agricultural preparations is poorly characterised in humans, and a valid histopathology scoring system is needed in a relevant animal model to further investigate the disease and potential treatments. We conducted two pilot studies in anesthetized minipigs, which are commonly used for toxicological studies. In the first, pigs were given 2.5 mL/kg of either OP (n = 4) or saline (n = 2) by gavage and compared with p

SUBMITTER: Hulse EJ 

PROVIDER: S-EPMC7556475 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature