Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice.

ABSTRACT: Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic treatment failure, and risk factors such as malnutrition and related micronutrient deficiencies. Individuals in sub-Saharan Africa are disproportionately affected by non-typhoidal S. enterica bloodstream infections. To inform a clinical trial in people, we investigated vitamin A as a treatment in the context of antibiotic treatment failure in a mouse model of vitamin A deficiency. Vitamin A-deficient (VAD) mice exhibited higher systemic bacterial levels with a multidrug-resistant clinical isolate in comparison to mice on a control diet. Sex-specific differences in vitamin A deficiency and disseminated infec

SUBMITTER: Stull-Lane AR 

PROVIDER: S-EPMC7556496 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature