Higher vascularity at infiltrated peripheral edema differentiates proneural glioblastoma subtype.

ABSTRACT:

Background and purpose

Genetic classifications are crucial for understanding the heterogeneity of glioblastoma. Recently, perfusion MRI techniques have demonstrated associations molecular alterations. In this work, we investigated whether perfusion markers within infiltrated peripheral edema were associated with proneural, mesenchymal, classical and neural subtypes.

Materials and methods

ONCOhabitats open web services were used to obtain the cerebral blood volume at the infiltrated peripheral edema for MRI studies of 50 glioblastoma patients from The Cancer Imaging Archive: TCGA-GBM. ANOVA and Kruskal-Wallis tests were carried out in order to assess the association between vascular features and the Verhaak subtypes. For assessing specific differences, Mann-Whitney U-test was

SUBMITTER: Chelebian E 

PROVIDER: S-EPMC7556526 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature