The mediating effects of public genomic knowledge in precision medicine implementation: A structural equation model approach.

ABSTRACT: Precision medicine emphasizes predictive, preventive and personalized treatment on the basis of information gleaned from personal genetic and environmental data. Its implementation at health systems level is regarded as multifactorial, involving variables associated with omics technologies, public genomic awareness and adoption tendencies for new medical technologies. However, interrelationships of the various factors and their synergy has not been sufficiently quantified. Based on a survey of 270 participants involved in the use of molecular tests (omics-based biomarkers, OBMs), this study examined how characteristics of omics biomarkers influence precision medicine implementation outcomes (ImO) through an intermediary factor, public genomic awareness (represented by User Response, UsR).

SUBMITTER: Mogaka JJO 

PROVIDER: S-EPMC7556538 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature