Microvascular dysfunction in COVID-19: the MYSTIC study.

ABSTRACT:

Rationale

Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ failure in COVID-19.

Objectives

To comprehensively characterize and quantify microvascular alterations in patients with COVID-19.

Methods

Hospitalized adult patients with moderate-to-severe or critical COVID-19 (n = 23) were enrolled non-consecutively in this prospective, observational, cross-sectional, multi-center study. Fifteen healthy volunteers served as controls. All participants underwent intravital microscopy by sidestream dark field imaging to quantify vascular density, red blood cell velocity (V_RBC), and glycocalyx dimensions (perfused boundary region, PBR) in sublingua

SUBMITTER: Rovas A 

PROVIDER: S-EPMC7556767 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature