Incidence of hypothyroidism after treatment for breast cancer-a Danish matched cohort study.

ABSTRACT:

Background

Breast cancer survivors (BCS) may have increased risk of hypothyroidism, but risk according to treatment modality is unclear. We estimated the incidence of hypothyroidism in women with breast cancer, and according to cancer treatment.

Methods

Using nationwide registries, we identified all Danish women aged ≥ 35 years diagnosed with non-metastatic breast cancer (1996-2009). We matched up to five cancer-free women (controls) for each BCS. We excluded women with prevalent thyroid disease. Cancer treatment was chemotherapy with or without radiotherapy (RT) targeting the breast/chest wall only, or also the lymph nodes (RTn). We identified hypothyroidism using diagnostic codes, and/or levothyroxine prescriptions. We calculated the cumulative incidence, incidence rates (

SUBMITTER: Falstie-Jensen AM 

PROVIDER: S-EPMC7556927 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature