Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey.

ABSTRACT:

Background

The BRCA mutation (BRCAm) in males has been reported to confer a higher risk for the development of various tumors. However, little is known about its clinicopathologic features and prognostic implications.

Design

We conducted a retrospective pan-tumor survey on 346 cases of BRCA-associated tumors in males. Comparative analyses were conducted among male and female patients with BRCAm (n = 349), as well as in male patients without BRCAm (n = 4577).

Results

Similar incidences of BRCAm (6.0 vs. 6.6%) and age at diagnosis of tumor (median, 65 vs. 60 years) were observed in male and female patients. Carcinomas of the lung, bladder, stomach, and cutaneous melanoma were the frequent tumors demonstrating BRCAm in males, of which the majority were stage II or III di

SUBMITTER: Sun P 

PROVIDER: S-EPMC7556962 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature