A combined risk score enhances prediction of type 1 diabetes among susceptible children.

ABSTRACT: Type 1 diabetes (T1D)-an autoimmune disease that destroys the pancreatic islets, resulting in insulin deficiency-often begins early in life when islet autoantibody appearance signals high risk¹. However, clinical diabetes can follow in weeks or only after decades, and is very difficult to predict. Ketoacidosis at onset remains common^2,3 and is most severe in the very young^4,5, in whom it can be life threatening and difficult to treat^6-9. Autoantibody surveillance programs effectively prevent most ketoacidosis^10-12 but require frequent evaluations whose expense limits public health adoption¹³. Prevention therapies applied before onset, when greater islet mass remains, have rarely been feasible¹⁴ because individuals

SUBMITTER: Ferrat LA 

PROVIDER: S-EPMC7556983 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature