The role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis.

ABSTRACT:

Background

Angiogenesis plays a central role in the pathophysiology of rheumatic diseases. Patients with psoriatic arthritis (PsA) demonstrate increased vascularity over patients with rheumatoid arthritis (RA), with unknown mechanisms.

Methods

We evaluated the serum levels of several pro- and anti-angiogenic factors in 62 PsA patients with active disease, 39 PsA patients in remission, 33 active RA patients, and 33 healthy controls (HC). Additionally, we used an in vitro co-culture system of fibroblast (HT1080) and monocytic-like (MM6) cell lines, to evaluate how their interactions affect the secretion of angiogenic factors and angiogenesis promoting abilities using scratch and tube formation assays.

Results

PsA patients, regardless of disease activity, exhibited highe

SUBMITTER: Rahat MA 

PROVIDER: S-EPMC7557017 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature