ProteiNorm - A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification.

ABSTRACT: The technological advances in mass spectrometry allow us to collect more comprehensive data with higher quality and increasing speed. With the rapidly increasing amount of data generated, the need for streamlining analyses becomes more apparent. Proteomics data is known to be often affected by systemic bias from unknown sources, and failing to adequately normalize the data can lead to erroneous conclusions. To allow researchers to easily evaluate and compare different normalization methods via a user-friendly interface, we have developed "proteiNorm". The current implementation of proteiNorm accommodates preliminary filters on peptide and sample levels followed by an evaluation of several popular normalization methods and visualization of the missing value. The user then selects an adequat

SUBMITTER: Graw S 

PROVIDER: S-EPMC7557219 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature