Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples.

ABSTRACT: The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulati

SUBMITTER: Leng L 

PROVIDER: S-EPMC7557250 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature