Radio-Sensitizing Effects of Cu^II and Zn^II Complexes of Ornidazole: Role of Nitro Radical Anion.

ABSTRACT: The treatment of malignant cells that are deficient in oxygen due to the insufficient flow of blood is often seen as a major hindrance in radiotherapy. Such cells become radio-resistant because molecular oxygen, the natural and best radio-sensitizer, is depleted. Hence, to compensate this deficiency in oxygen, there is a need for agents that enhance radiation-induced damage of cells (radio-sensitizers) in a manner that normal cells are least affected. Simultaneously, agents capable of showing activity under hypoxic conditions are known as hypoxic cytotoxins that selectively and preferably destroy cells under hypoxic environments. 5-Nitroimidazoles fit both definitions. Their efficiency is based on their ability to generate the nitro radical anion that interacts with the strands of DNA with

SUBMITTER: Nandy P 

PROVIDER: S-EPMC7557252 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature