Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England.

ABSTRACT:

Background

Understanding of the true asymptomatic rate of infection of SARS-CoV-2 is currently limited, as is understanding of the population-based seroprevalence after the first wave of COVID-19 within the UK. The majority of data thus far come from hospitalised patients, with little focus on general population cases, or their symptoms.

Methods

We undertook enzyme linked immunosorbent assay characterisation of IgM and IgG responses against SARS-CoV-2 spike glycoprotein and nucleocapsid protein of 431 unselected general-population participants of the TwinsUK cohort from South-East England, aged 19-86 (median age 48; 85% female). 382 participants completed prospective logging of 14 COVID-19 related symptoms via the COVID Symptom Study App, allowing consideration of serology a

SUBMITTER: Wells PM 

PROVIDER: S-EPMC7557299 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature