Contribution of Genetics to the Susceptibility to Hidradenitis Suppurativa in a Large, Cross-sectional Dutch Twin Cohort.

ABSTRACT:

Importance

Hidradenitis suppurativa is a chronic, inflammatory skin disease in which genetic factors are considered to play a role, with up to 38% of patients reporting a family history. Variations in the γ-secretase genes are found mainly in familial cases with an autosomal dominant pattern of inheritance. These variations are rare in the general population with hidradenitis suppurativa, even in patients who report a family history of the disease.

Objective

To assess the heritability of hidradenitis suppurativa in a nationwide Dutch twin cohort.

Design, setting, and participants

In this cross-sectional study on self-reported hidradenitis suppurativa conducted from 2011 to 2016, data were collected from twins participating in the surveys of the nationwide Netherlands

SUBMITTER: van Straalen KR 

PROVIDER: S-EPMC7557497 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature