Effect of Tropisetron on Prevention of Emergence Delirium in Patients After Noncardiac Surgery: A Trial Protocol.

ABSTRACT:

Importance

Postoperative delirium is a frequent disorder for patients undergoing surgery and is associated with poor outcomes. Delirium may occur in the immediate period after anesthesia administration and surgery. Tropisetron, which is frequently administrated for postoperative nausea and vomiting, is also a partial agonist of α7 nicotinic acetylcholine receptors associated with neuroprotective effects. Tropisetron may be the potential pharmacological treatment to decrease delirium after noncardiac surgery.

Objective

To perform a randomized clinical trial to determine the efficacy and safety of tropisetron for prevention of emergence delirium in patients undergoing noncardiac surgery.

Design, setting, and participants

This single-center, 2-arm randomized, double-blin

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7557499 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature