Predicting antidepressant response by monitoring early improvement of individual symptoms of depression: individual patient data meta-analysis.

ABSTRACT:

Background

Improvement in depression within the first 2 weeks of antidepressant treatment predicts good outcomes, but non-improvers can still respond or remit, whereas improvers often do not.AimsWe aimed to investigate whether early improvement of individual depressive symptoms better predicts response or remission.

Method

We obtained individual patient data of 30 trials comprising 2184 placebo-treated and 6058 antidepressant-treated participants. Primary outcome was week 6 response; secondary outcomes were week 6 remission and week 12 response and remission. We compared models that only included improvement in total score by week 2 (total improvement model) with models that also included improvement in individual symptoms.

Results

For week 6 response, the area under

SUBMITTER: de Vries YA 

PROVIDER: S-EPMC7557872 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature