Skin hydration dynamics investigated by electrical impedance techniques in vivo and in vitro.

ABSTRACT: Skin is easily accessible for transdermal drug delivery and also attractive for biomarker sampling. These applications are strongly influenced by hydration where elevated hydration generally leads to increased skin permeability. Thus, favorable transdermal delivery and extraction conditions can be easily obtained by exploiting elevated skin hydration. Here, we provide a detailed in vivo and in vitro investigation of the skin hydration dynamics using three techniques based on electrical impedance spectroscopy. Good correlation between in vivo and in vitro results is demonstrated, which implies that simple but realistic in vitro models can be used for further studies related to skin hydration (e.g., cosmetic testing). Importantly, the results show that hydration proceeds in two stages. First

SUBMITTER: Morin M 

PROVIDER: S-EPMC7557913 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature