Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis.

ABSTRACT: Tuberculosis-causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells. During the activation of host defence mechanisms also neutrophils and T helper 1 (T_H1) and T_H17 cells are recruited to the site of infection. The T_H17 cell-derived interleukin (IL)-17 in turn induces the cathelicidin LL37 which shows direct antimycobacterial effects. Here, we investigated the role of IL-26, a T_H1- and T_H17-associated cytokine that exhibits antimicrobial activity. We found that both IL-26 mRNA and protein are strongly increased in tuberculous lymph nodes. Furthermore, IL-26 is able to directly kill Mtb and decrease the infection rate in macrophages. Binding of IL-

SUBMITTER: Hawerkamp HC 

PROVIDER: S-EPMC7558018 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature