Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci.

ABSTRACT: The genus Enterococcus comprises a ubiquitous group of Gram-positive bacteria that can cause diverse health care-associated infections. Their genome plasticity enables easy acquisition of virulence factors as well as antibiotic resistances. Urinary tract infections (UTIs) and catheter-associated UTIs are common diseases caused by enterococci. In this study, Enterococcus strains isolated from UTIs were characterized, showing that the majority were E. faecalis and contained several virulence factors associated to a better colonization of the urinary tract. Their susceptibility against the bacteriocin AS-48 and several antibiotics was tested. AS-48 is a potent circular bacteriocin that causes bacterial death by pore formation in the cell membrane. The interest of this bacteriocin is based on

SUBMITTER: Montalban-Lopez M 

PROVIDER: S-EPMC7558097 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature