Education, Smoking and CRP Genetics in Relation to C-Reactive Protein Concentrations in Black South Africans.

ABSTRACT: Because elevated circulating C-reactive protein (CRP) and low socio-economic status (SES), have both been implicated in cardiovascular disease development, we investigated whether SES factors associate with and interact with CRP polymorphisms in relation to the phenotype. Included in the study were 1569 black South Africans for whom CRP concentrations, 12 CRP single nucleotide polymorphisms (SNPs), cardiovascular health markers, and SES factors were known. None of the investigated SES aspects was found to associate with CRP concentrations when measured individually; however, in adjusted analyses, attaining twelve or more years of formal education resulted in a hypothetically predicted 18.9% lower CRP concentration. We also present the first evidence that active smokers with a

SUBMITTER: Myburgh PH 

PROVIDER: S-EPMC7558133 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature