Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis.

ABSTRACT: We have previously described hypomorphic reelin (Reln) mutant mice, Reln^CTRdel, in which the morphology of the dentate gyrus is distinct from that seen in reeler mice. In the Reln^CTRdel mutant, the infrapyramidal blade of the dentate gyrus fails to extend, while the suprapyramidal blade forms with a relatively compact granule neuron layer. Underlying this defect, we now report several developmental anomalies in the RelnCTRdel dentate gyrus. Most strikingly, the distribution of Cajal-Retzius cells was aberrant; Cajal-Retzius neurons were increased in the suprapyramidal blade, but were greatly reduced along the subpial surface of the prospective infrapyramidal blade. We also observed multiple abnormalities of the fimbriodentate

SUBMITTER: Ha S 

PROVIDER: S-EPMC7558149 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature