Antibiotic Treatment in Anopheles coluzzii Affects Carbon and Nitrogen Metabolism.

ABSTRACT: The mosquito microbiota reduces the vector competence of Anopheles to Plasmodium and affects host fitness; it is therefore considered as a potential target to reduce malaria transmission. While immune induction, secretion of antimicrobials and metabolic competition are three typical mechanisms of microbiota-mediated protection against invasive pathogens in mammals, the involvement of metabolic competition or mutualism in mosquito-microbiota and microbiota-Plasmodium interactions has not been investigated. Here, we describe a metabolome analysis of the midgut of Anopheles coluzzii provided with a sugar-meal or a non-infectious blood-meal, under conventional or antibiotic-treated conditions. We observed that the antibiotic treatment affects the tricarboxylic acid

SUBMITTER: Chabanol E 

PROVIDER: S-EPMC7558193 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature